In Yakuza: Like a Dragon, Yokohama is the main setting for the majority of the game.
Protagonist Kazuma Kiryu was born in Yokohama on June 17th, 1968. During the 1980s, Lau Ka Long of the Snake Flower Triad took control of the Yokohama underworld, setting up his base of operations in a large Chinese restaurant in the city.
Kiryu travels to Yokohama to find Haruka, who is held captive by the Snake Flower Triad.
The intro conversation with Daigo in his car is shown to be in Yokohama, Chinatown (only in the Remastered edition). Goh Hamazaki strikes a deal with the Snake Flower Triad to take control of the city's underworld. He is seen blowing up a small Chinese restaurant and killing its owner.